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Indirectly radioiodinated exendin-4 as an analytical tool for in vivo detection of glucagon-like peptide-1 receptor in a disease setting

ConclusionOur results suggested that [123I]Ex4ipm could be valuable for GLP-1R imaging in diabetes, insulinomas, and various diseases related to GLP-1R. (Source: Annals of Nuclear Medicine)

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https://medworm.com/828532125/indirectly-radioiodinated-exendin-4-as-an-analytical-tool-for-in-vivo-detection-of-glucagon-like-pep/

Value of 18 F-FDG PET/CT for prognostic stratification in patients with primary intestinal diffuse large B cell lymphoma treated with an R-CHOP-like regimen

ConclusionsHigh TLG, non-GCB and high NCCN-IPI can identify a subset of PI-DLBCL patients with inferior survival outcomes. Furthermore, the grading system can identify PI-DLBCL patient groups with markedly different prognoses, which might contribute to the adjustment of the therapeutic regime. (Source: Annals of Nuclear Medicine)

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https://medworm.com/828196211/value-of-18-f-fdg-petct-for-prognostic-stratification-in-patients-with-primary-intestinal-diffuse-l/

Effect of sex on aging-related decline of dopamine transporter in healthy subjects

ConclusionsWe have shown that slopes of regression lines of DAT availabilities and age were significantly different between young and old subjects in females, not in males. Therefore, sex has an impact on aging-related decline of striatal DAT availability. (Source: Annals of Nuclear Medicine)

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https://medworm.com/827859055/effect-of-sex-on-aging-related-decline-of-dopamine-transporter-in-healthy-subjects/

Reactor produced [ 64 Cu]CuCl 2 as a PET radiopharmaceutical for cancer imaging: from radiochemistry laboratory to nuclear medicine clinic

ConclusionsTo the best of our knowledge, this is the first study on use of reactor produced [64Cu]CuCl2 for PET imaging of cancer in human patients. It is envisaged that this route of production of64Cu would aid towards affordable availability of this radioisotope for widespread clinical use in countries with limited cyclotron facilities. (Source: Annals of Nuclear Medicine)

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https://medworm.com/827691419/reactor-produced-64-cucucl-2-as-a-pet-radiopharmaceutical-for-cancer-imaging-from-radiochemistry/

Immune microenvironment of the gene signature reflecting the standardised uptake value on 18 F-fluorodeoxyglucose positron emission tomography/computed tomography in head and neck squamous cell carcinoma

ConclusionHNSC exhibited the distinct TIM according to the gene signature reflecting SUVmax on18F-FDG PET/CT. Our results support an understanding of the close relationship between FDG uptake and tumor immune response, and suggest that18F-FDG PET/CT could be clinically usable as a biomarker for assisting immunotherapy. (Source: Annals of Nuclear Medicine)

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https://medworm.com/827357015/immune-microenvironment-of-the-gene-signature-reflecting-the-standardised-uptake-value-on-18-f-fluor/

Comparison of diagnostic accuracy between [ 18 F]FDG PET/MRI and contrast-enhanced MRI in T staging for oral tongue cancer

ConclusionsAlthough shallow DOIs are often overestimated, regional [18F]FDG PET/MRI without fat suppression and gadolinium enhancement is comparable to and may be substituted for ceMRI in preoperative T staging for OTC patients, reducing metal artifacts and avoiding the adverse effects of GBCAs. (Source: Annals of Nuclear Medicine)

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https://medworm.com/826851279/comparison-of-diagnostic-accuracy-between-18-ffdg-petmri-and-contrast-enhanced-mri-in-t-staging-/

Comparison of 18 F-FDG PET/CT and 67 Ga-SPECT for the diagnosis of fever of unknown origin: a multicenter prospective study in Japan

ConclusionsFDG-PET/CT showed a superior sensitivity to67Ga-SPECT for the identification of the site of greatest importance for the final diagnosis of the cause of FUO. (Source: Annals of Nuclear Medicine)

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https://medworm.com/826514732/comparison-of-18-f-fdg-petct-and-67-ga-spect-for-the-diagnosis-of-fever-of-unknown-origin-a-multic/

Effects of feeding condition on the myocardial and hepatic accumulation of radioiodine-labeled BMIPP in mice

ConclusionAlthough short-period (6  h) fasting did not affect the myocardial accumulation level of [125I]BMIPP, the hepatic accumulation level was increased. The present results indicate that the fed condition may provide higher-contrast images in myocardial [123I]BMIPP scintigraphy. (Source: Annals of Nuclear Medicine)

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https://medworm.com/826180567/effects-of-feeding-condition-on-the-myocardial-and-hepatic-accumulation-of-radioiodine-labeled-bmipp/

Prognostic value of the baseline 18F-FDG PET/CT metabolic tumour volume (MTV) and further stratification in low-intermediate (L-I) and high-intermediate (H-I) risk NCCNIPI subgroup by MTV in DLBCL MTV predict prognosis in DLBCL

ConclusionsMTV, as a tumor metabolic volume parameter, and the NCCNIPI score were independent predictors of prognosis in general DLBCL patients. In the low-intermediate and high-intermediate NCCNIPI subgroup, we further confirm the risk stratification abilities of MTV, which could add the prognostic value of NCCNIPI. (Source: Annals of Nuclear Medicine)

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https://medworm.com/824351104/prognostic-value-of-the-baseline-18f-fdg-petct-metabolic-tumour-volume-mtv-and-further-stratifica/

Peripheral benzodiazepine receptor/18  kDa translocator protein positron emission tomography imaging in a rat model of acute brain injury

ConclusionsPET signal enhancement by PBR/TSPO at the site of brain injury correlated with the activation of microglia and production of inflammatory cytokines. Furthermore, because FEPPA enables the detection of neurotoxic microglia on PET images, we successfully constructed a novel PET detection system that can monitor neurodegenerative diseases. (Source: Annals of Nuclear Medicine)

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https://medworm.com/823693489/peripheral-benzodiazepine-receptor18-kda-translocator-protein-positron-emission-tomography-imagin/

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