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High detection sensitivity and reliable morphological correlation of PET with a silicon photomultiplier for primary tongue squamous cell carcinoma

ConclusionsThe SiPM PET provides better detection sensitivity and a reliable morphological correlation for the T1/T2 primary tongue tumors than the non-SiPM PET due to its high performance. (Source: Annals of Nuclear Medicine)

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18 F-FDG uptake as a predictive factor for progressive aortic enlargement in aortic dissection

ConclusionsHigher18F-FDG uptake in the dissected aortic wall as determined by TBR is associated with increased risk of PAE in patients with medically treated AD. TBR shows good specificity and negative predictive value for predicting PAE. (Source: Annals of Nuclear Medicine)

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Quantitative evaluation of anti-resorptive agent-related osteonecrosis of the jaw using bone single photon emission computed tomography in clinical settings: relationship between clinical stage and imaging

ConclusionMBV, which includes the concept of volume, showed significant differences between clinical stages and tended to increase with the stage increase. As an objective and reliable indicator, MBV might be an adjunct diagnostic method for staging ARONJ. (Source: Annals of Nuclear Medicine)

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Accuracy of metabolic volume and total glycolysis among six threshold-based target segmentation algorithms

ConclusionsOf the six threshold-based segmentation methods studied, ThCOA was the most accurate method for evaluating MV and TG and had only minor dependence on TBRs and sphere size. The small voxel sizes improved the variation of the accuracy in low TBR. (Source: Annals of Nuclear Medicine)

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Assessing the effects of body weight on subchondral bone formation with quantitative 18 F-sodium fluoride PET

ConclusionsThese preliminary data demonstrate the feasibility and reliability of assessing bone turnover at the joints using quantitative NaF-PET. Our findings corroborate the fact that biomechanical factors including mechanical loading and weight-bearing are contributors to osteoarthritis disease progression. (Source: Annals of Nuclear Medicine)

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Improvement of biodistribution profile of a radiogallium-labeled, αvβ6 integrin-targeting peptide probe by incorporation of negatively charged amino acids

ConclusionWe have successfully reduced the nonspecific uptake in the liver and spleen by altering the linker amino acid from G6 to D6. [67Ga]CD6 overcame the drawbacks of [67Ga]CG6 in its biodistribution. (Source: Annals of Nuclear Medicine)

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Detectable size of melanoma metastases to brain on PET/CT

ConclusionsPET/CT can detect metastatic melanoma lesions over about 2  cm in size, with hot lesions generally visible at smaller sizes. (Source: Annals of Nuclear Medicine)

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Diagnostic utility and characteristics of CT-based attenuation correction in brain perfusion SPECT/CT in predicting the exacerbation of Alzheimer changes from mild cognitive impairment utilizing voxel-based statistical analysis in comparison with Chang ’s method

ConclusionsCT-AC may allow brain perfusion SPECT to reflect more exact neuropathic changes in MCI that would cause progression of early AD. CT-AC in conjunction with voxel-based statistical analysis could possess higher diagnostic accuracy for exacerbation of disease implying early Alzheimer changes in MCI patients, with decreases in cerebral perfusion in the left temporal and limbic lobes representing good indicators. (Source: Annals of Nuclear Medicine)

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Applying Wells score to inconclusive perfusion only modified PIOPED II (Prospective Investigation of Pulmonary Embolism Diagnosis II) readings in order  to optimize the lung scintigraphy diagnostic yield in acute pulmonary embolism detection

ConclusionAdding Wells score to non-diagnostic scans allowed identification of PE to be done reliably, and provided further insight into how lung scintigraphy in conjunction with clinical assessment is a practical strategy not only for the patients unfit for performing CTPA but also in all the patients referred for PE evaluation. (Source: Annals of Nuclear Medicine)

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